[HTML][HTML] Regulation of Alternative Splicing of Protein Kinase Cβ by Insulin∗
CE Chalfant, H Mischak, JE Watson, BC Winkler… - Journal of Biological …, 1995 - ASBMB
Insulin regulates a diverse array of cellular signaling processes involved in the control of
growth, differentiation, and cellular metabolism. Insulin increases glucose transport via a …
growth, differentiation, and cellular metabolism. Insulin increases glucose transport via a …
Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer
M Shiota, A Yokomizo, A Takeuchi, K Imada… - Clinical Cancer …, 2014 - AACR
Purpose: The progression of prostate cancer to metastatic and castration-resistant disease
represents a critical step. We previously showed that the transcription factor Twist1, which …
represents a critical step. We previously showed that the transcription factor Twist1, which …
Enhancement of the antiproliferative activity of cis‐diamminedichloroplatinum (II) by quercetin
J Hofmann, HH Fiebig, BR Winterhalter… - … journal of cancer, 1990 - Wiley Online Library
We have shown previously that the flavonoid quercetin (3, 3′, 4′, 5, 7‐
pentahydroxyflavone) enhances the antiproliferative activity of cis …
pentahydroxyflavone) enhances the antiproliferative activity of cis …
Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C
G Caravatti, T Meyer, A Fredenhagen, U Trinks… - Bioorganic & Medicinal …, 1994 - Elsevier
The synthesis and in vitro protein kinase C (PKC) inhibition of a series of staurosporine
derivatives is described. Essential for activity is a free NH of the lactam portion of the …
derivatives is described. Essential for activity is a free NH of the lactam portion of the …
Benzopyranones and Benzothiopyranones: A Class of Tyrosine Protein Kinase Inhibitors with Selectivity for the v-abl Kinase
JF Geissler, JL Roesel, T Meyer, UP Trinks, P Traxler… - Cancer Research, 1992 - AACR
Abelson murine leukemia virus is an acutely transforming replication-defective virus which
encodes a transforming protein with tyrosine-specific protein kinase activity. A variety of …
encodes a transforming protein with tyrosine-specific protein kinase activity. A variety of …
4, 5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo …
E Buchdunger, U Trinks, H Mett… - Proceedings of the …, 1994 - National Acad Sciences
Deregulated signal transduction via the epidermal growth factor receptor (EGF-R) family of
protein-tyrosine kinase growth factor receptors is associated with proliferative diseases. We …
protein-tyrosine kinase growth factor receptors is associated with proliferative diseases. We …
Activation of protein kinase C subtypes α, γ, δ, ϵ, ζ, and η by tumor-promoting and nontumor-promoting agents
D Geiges, T Meyer, B Marte, M Vanek… - Biochemical …, 1997 - Elsevier
Protein kinase C (PKC) subtypes α, γ, δ, ϵ, ζ, and η have been expressed using the
baculovirus expression system. The partially purified PKC subtypes have been studied for …
baculovirus expression system. The partially purified PKC subtypes have been studied for …
[HTML][HTML] Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.
JF Geissler, P Traxler, U Regenass, BJ Murray… - Journal of Biological …, 1990 - Elsevier
Various derivatives of thiazolidine-diones have been identified as tyrosine protein kinase
inhibitors. The epidermal growth factor (EGF) receptor kinase and c-src kinase were …
inhibitors. The epidermal growth factor (EGF) receptor kinase and c-src kinase were …
Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching
P Furet, G Bold, F Hofmann, P Manley, T Meyer… - Bioorganic & medicinal …, 2003 - Elsevier
The vascular endothelial growth factor (VEGF) tyrosine kinase receptors KDR and Flt-1 are
targets of current interest in anticancer drug research. PTK787/ZK222584 is a potent …
targets of current interest in anticancer drug research. PTK787/ZK222584 is a potent …
Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells
F Stölzel, C Steudel, U Oelschlägel, B Mohr, S Koch… - Annals of …, 2010 - Springer
Abstract Treatment of acute myeloid leukemia (AML) remains challenging with many
patients harboring unfavorable prognostic parameters such as FLT3 internal tandem …
patients harboring unfavorable prognostic parameters such as FLT3 internal tandem …