Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: Current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma

T Wu, Y Liu, Y Cao, Z Liu - Advanced Materials, 2022 - Wiley Online Library
Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …

[HTML][HTML] The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy

Y Shi, R van der Meel, X Chen, T Lammers - Theranostics, 2020 - ncbi.nlm.nih.gov
Following its discovery more than 30 years ago, the enhanced permeability and retention
(EPR) effect has become the guiding principle for cancer nanomedicine development. Over …

Brain co‐delivery of temozolomide and cisplatin for combinatorial glioblastoma chemotherapy

Y Zou, Y Wang, S Xu, Y Liu, J Yin… - Advanced …, 2022 - Wiley Online Library
Glioblastoma (GBM) is an intractable malignancy with high recurrence and mortality.
Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows …

Organic semiconducting macromolecular dyes for NIR‐II photoacoustic imaging and photothermal therapy

C Yin, X Li, Y Wang, Y Liang, S Zhou… - Advanced Functional …, 2021 - Wiley Online Library
Owing to the unique advantages of photoacoustic imaging (PAI) and photothermal therapy
(PTT) conducted over the near‐infrared‐II (NIR‐II) window, the development of high …

Brain co‐delivery of first‐line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy

Y Liu, W Wang, D Zhang, Y Sun, F Li, M Zheng… - …, 2022 - Wiley Online Library
Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid
development of resistance to mono chemotherapy and poor brain targeted delivery …

An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy

S Liu, J Liu, H Li, K Mao, H Wang, X Meng, J Wang… - Biomaterials, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor
with a high mortality rate. Immunotherapy has achieved promising clinical results in multiple …

Overview of current drug delivery methods across the blood–brain barrier for the treatment of primary brain tumors

R Haumann, JC Videira, GJL Kaspers… - CNS drugs, 2020 - Springer
Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

Mechanisms of resistance and current treatment options for glioblastoma multiforme (GBM)

SSK Yalamarty, N Filipczak, X Li, MA Subhan… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is one of the hardest-to-treat brain tumors, often
resistant to conventional treatments such as chemotherapy and radiation therapy. Despite …