Advances in Glioblastoma Therapy: An Update on Current Approaches

RS Angom, NMR Nakka, S Bhattacharya - Brain Sciences, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is a primary malignant brain tumor characterized by a high
grade of malignancy and an extremely unfavorable prognosis. The current efficacy of …

Precision medicine-guided co-delivery of ASPN siRNA and oxaliplatin by nanoparticles to overcome chemoresistance of colorectal cancer

CZ Huang, Y Zhou, QS Tong, QJ Duan, Q Zhang, JZ Du… - Biomaterials, 2022 - Elsevier
The development of chemoresistance is a major hurdle for the treatment of colorectal cancer
(CRC), which contributes remarkably to the poor clinical prognosis. Nanodrug delivery …

Long-acting therapeutic delivery systems for the treatment of gliomas

S Padmakumar, MM Amiji - Advanced Drug Delivery Reviews, 2023 - Elsevier
Despite the emergence of cutting-edge therapeutic strategies and tremendous progress in
research, a complete cure of glioma remains elusive. The heterogenous nature of tumor …

Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies

H Goel, V Kalra, SK Verma, SK Dubey… - Journal of Controlled …, 2022 - Elsevier
Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …

[HTML][HTML] Treatment of glioblastoma with re-purposed renin-angiotensin system modulators: Results of a phase I clinical trial

M O'Rawe, AC Wickremesekera, R Pandey… - Journal of Clinical …, 2022 - Elsevier
Glioblastoma is the most common and most aggressive primary brain cancer in adults.
Standard treatment of glioblastoma consisting of maximal safe resection, adjuvant …

Image‐guided diagnosis and treatment of glioblastoma

Y Bian, Y Wang, X Chen, Y Zhang, S Xiong, D Su - View, 2023 - Wiley Online Library
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and
high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and …

Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine

HS Sharma, DF Muresanu, A Nozari… - International review of …, 2020 - Elsevier
Glioblastoma Multiforme (GBM) is one the most common intracranial tumors discovered by
Burns (1800) and Abernethy (1804) based on gross morphology of the autopsied material …

[HTML][HTML] Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier …

C Brighi, L Reid, LA Genovesi, M Kojic, A Millar… - Theranostics, 2020 - ncbi.nlm.nih.gov
The clinical translation of new nanoparticle-based therapies for high-grade glioma (HGG)
remains extremely poor. This has partly been due to the lack of suitable preclinical mouse …

Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety

Y Zhou, L Wang, L Chen, W Wu, Z Yang, Y Wang… - Nano Research, 2023 - Springer
Glioblastoma (GBM) has been regarded as one of the most deadly and challenging cancers
to treat with extremely poor prognosis. The limited efficacy of current chemotherapies might …

Pathogenetic features and current management of glioblastoma

HM Nguyen, K Guz-Montgomery, DB Lowe, D Saha - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most common form of primary malignant brain
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …