The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …
Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
M Bader - Annual review of pharmacology and toxicology, 2010 - annualreviews.org
The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …
Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones1
EG Erdös, RA Skidgel - The FASEB journal, 1989 - Wiley Online Library
This report summarizes the recent rapid development of research on neutral endopeptidase
24.11 (enkephalinase; NEP) and on two other metalloenzymes, meprin and endopeptidase …
24.11 (enkephalinase; NEP) and on two other metalloenzymes, meprin and endopeptidase …
Update on tissue renin–angiotensin systems
M Bader, D Ganten - Journal of Molecular Medicine, 2008 - Springer
Angiotensin (Ang) II is not only generated in the circulation by renin and angiotensin-
converting enzyme (ACE) but also is produced locally in numerous organs including kidney …
converting enzyme (ACE) but also is produced locally in numerous organs including kidney …
Regulation of intrarenal angiotensin II in hypertension
LG Navar, LM Harrison-Bernard, A Nishiyama… - …, 2002 - Am Heart Assoc
Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving
formation from both systemically delivered and intrarenally formed substrate, as well as …
formation from both systemically delivered and intrarenally formed substrate, as well as …
3D proximal tubule tissues recapitulate key aspects of renal physiology to enable nephrotoxicity testing
SM King, JW Higgins, CR Nino, TR Smith… - Frontiers in …, 2017 - frontiersin.org
Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a
primary site of nephrotoxicity and resulting attrition in the drug development pipeline …
primary site of nephrotoxicity and resulting attrition in the drug development pipeline …
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
M Bader, J Peters, O Baltatu, DN Müller, FC Luft… - Journal of molecular …, 2001 - Springer
Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …
Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet
This study was performed to examine whether there is an inappropriate regulation of
intrarenal angiotensinogen in Dahl-salt sensitive rats (DS) fed a high salt diet (HS). Dahl salt …
intrarenal angiotensinogen in Dahl-salt sensitive rats (DS) fed a high salt diet (HS). Dahl salt …
Angiotensin actions in the kidney: renewed insight into the old hormone
I Ichikawa, RC Harris - Kidney international, 1991 - Elsevier
Since the recognition of its potent vasoconstrictor action in the renal circulation, angiotensin
II (Ang II) has several times come into the forefront in the nephrology community by revealing …
II (Ang II) has several times come into the forefront in the nephrology community by revealing …
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells
FJ Warner, RA Lew, AI Smith, DW Lambert… - Journal of Biological …, 2005 - ASBMB
Angiotensin-converting enzyme-2 (ACE2) is a homologue of angiotensin-I converting
enzyme (ACE), the central enzyme of the renin-angiotensin system (RAS). ACE2 is …
enzyme (ACE), the central enzyme of the renin-angiotensin system (RAS). ACE2 is …