In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …

This report summarizes the recent rapid development of research on neutral endopeptidase
24.11 (enkephalinase; NEP) and on two other metalloenzymes, meprin and endopeptidase …

Angiotensin (Ang) II is not only generated in the circulation by renin and angiotensin-
converting enzyme (ACE) but also is produced locally in numerous organs including kidney …

Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving
formation from both systemically delivered and intrarenally formed substrate, as well as …

Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a
primary site of nephrotoxicity and resulting attrition in the drug development pipeline …

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …

This study was performed to examine whether there is an inappropriate regulation of
intrarenal angiotensinogen in Dahl-salt sensitive rats (DS) fed a high salt diet (HS). Dahl salt …

Since the recognition of its potent vasoconstrictor action in the renal circulation, angiotensin
II (Ang II) has several times come into the forefront in the nephrology community by revealing …

Angiotensin-converting enzyme-2 (ACE2) is a homologue of angiotensin-I converting
enzyme (ACE), the central enzyme of the renin-angiotensin system (RAS). ACE2 is …