BACKGROUND In regions where prenatal screening for anencephaly and spina bifida is
widespread, many cases of these defects are diagnosed prenatally. The purpose of this …

In clinical practice, and in the medical literature, severe congenital malformations such as
trisomy 18, anencephaly, and renal agenesis are frequently referred to as 'lethal'or as …

Objective This revised guideline is intended to provide an update on the genetic aspects,
prevention, screening, diagnosis, and management of fetal neural tube defects. Target …

You have a long-standing relationship with a child who has severe neurologic impairment
due to mitochondrial (Leigh's) disease. At your last visit with this patient and family, his …

Background Pregnancy is a state of increased requirement of macro-and micronutrients, and
malnourishment or inadequate dietary intake before and during pregnancy, can lead to …

The fetal central nervous system can already be examined in the first trimester of pregnancy.
Acrania, alobar holoprosencephaly, cephaloceles, and spina bifida can confidently be …

Please cite this paper as: Wilkinson D, Thiele P, Watkins A, De Crespigny L. Fatally flawed?
A review and ethical analysis of lethal congenital malformations. BJOG 2012; 119: 1302 …

Objective: To evaluate the potential of the first-trimester ultrasound (US) features for the
detection of central nervous system (CNS) anomalies. Methods/Methodology: This is a …

OBJECTIVE: To estimate the risk of stillbirth (fetal death at 20 weeks of gestation or more)
associated with specific birth defects. METHODS: We identified a population-based …

Objective As advances in prenatal diagnosis increasingly enable detection of life-limiting
conditions, end-of-life care may start before birth. Termination of these pregnancies may …