Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …

Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …

Genome-wide association studies (GWAS) have identified several risk loci for post-traumatic
stress disorder (PTSD); however, how they confer PTSD risk remains unclear. We aimed to …

Alzheimer's disease (AD) is a common neurodegenerative disease in aging individuals.
Alternative splicing is reported to be relevant to AD development while their roles in etiology …

Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …

Genome‑wide association studies (GWASs) have revealed numerous loci associated with
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …

The hippocampal–entorhinal system supports cognitive function and is selectively
vulnerable to Alzheimer's disease (AD). Little is known about global transcriptomic changes …

Background Genome-wide association studies have identified dozens of genetic risk loci for
Alzheimer's disease (AD), yet the underlying causal variants and biological mechanisms …