The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/β‐catenin signalling pathway

Z Feng, C Jia, X Lin, H Hao, S Li, F Li, Q Cui… - Cell …, 2022 - Wiley Online Library
Objectives Necrotizing enterocolitis (NEC) is a catastrophic gastrointestinal emergency in
preterm infants, whose exact aetiology remains unknown. The role of lithocholic acid (LCA) …

Intestinal epithelial cell proliferation, apoptosis and expression of tight junction proteins in patients with obstructive jaundice

SF Assimakopoulos, AC Tsamandas… - European journal of …, 2011 - Wiley Online Library
Eur J Clin Invest 2011; 41 (2): 117–125 Abstract Background Intestinal hyperpermeability
has been repeatedly confirmed in patients with obstructive jaundice and is considered a …

Bile salts induce resistance to apoptosis through NF-κB-mediated XIAP expression

DJ Turner, SM Alaish, T Zou, JN Rao, JY Wang… - Annals of …, 2007 - journals.lww.com
Apoptosis plays a critical role in intestinal mucosal homeostasis. We previously showed that
the bile salt taurodeoxycholate has a beneficial effect on the intestinal mucosa through an …

Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line

K Jaiswal, C Lopez-Guzman… - American Journal …, 2006 - journals.physiology.org
Bile reflux has been implicated in the neoplastic progression of Barrett's esophagus (BE).
Bile salts increase proliferation in a Barrett's-associated adenocarcinoma cell line (SEG-1 …

Wound healing responses at the gastrointestinal epithelium: a close look at novel regulatory factors and investigative approaches

T Karrasch, C Jobin - Zeitschrift für Gastroenterologie, 2009 - thieme-connect.com
Zusammenfassung Eine einschichtige Lage von Epithelzellen kleidet den
Gastrointestinaltrakt höherer Lebewesen aus und trennt verschiedenste Antigene im Lumen …

Bile acid receptor TGR5 overexpression is associated with decreased intestinal mucosal injury and epithelial cell proliferation in obstructive jaundice

CG Ji, XL Xie, J Yin, W Qi, L Chen, Y Bai, N Wang… - Translational …, 2017 - Elsevier
Bile acids stimulate intestinal epithelial proliferation in vitro. We sought to investigate the role
of the bile acid receptor TGR5 in the protection of intestinal epithelial proliferation in …

Polysaccharides from Capsosiphon fulvescens Stimulate the Growth of IEC-6 Cells by Activating the MAPK Signaling Pathway

H Go, HJ Hwang, TJ Nam - Marine biotechnology, 2011 - Springer
Seaweed extracts show diverse bioactivities, such as antioxidant and antitumor activity.
Capsosiphon fulvescens is a green alga that is abundant along the southwest coast of South …

Identification and Characterization of MAPK Signaling Pathway Genes and Associated lncRNAs in the Ileum of Piglets Infected by Clostridium perfringens Type C

R Luo, X Huang, Z Yan, X Gao, P Wang… - BioMed research …, 2020 - Wiley Online Library
Clostridium perfringens type C (C. perfringens type C) is one of the main microbial
pathogens responsible for piglet diarrhea worldwide, causing substantial economic losses …

Bile acids: a bridge linking gut microbiota and NAFLD

J Zhang, C Wang, X Ji, F Wu, Z Lin… - Advanced Gut & …, 2022 - Wiley Online Library
Nowadays, nonalcoholic fatty liver disease (NAFLD) becomes the most common cause of
liver disease worldwide. Mounting evidence indicates that dysbiosis contributes to the …

Genistein combined polysaccharide (GCP) can inhibit intracrine androgen synthesis in prostate cancer cells

N Batra, A Sam, T Woldemariam, G Talbott… - Biomedicines, 2020 - mdpi.com
Our group and others have previously shown that genistein combined polysaccharide
(GCP), an aglycone isoflavone-rich extract with high bioavailability and low toxicity, can …