Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

Cytomegalovirus (CMV) is a β-herpesvirus present in a latent form in most people
worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious …

A range of emerging therapeutic approaches for the treatment of cancer aim to induce or
augment endogenous T cell responses. Chimeric antigen receptor (CAR) T cell therapy …

The adaptive immune system consists of T and B cells that express clonally distributed
antigen receptors. To achieve functional adaptive immune responses, antigen-specific T cell …

The ability of the human immune system to protect against infectious disease declines with
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …

Tissue-resident memory T cells (TRM cells) are a population of immune cells that reside in
the lymphoid and non-lymphoid organs without recirculation through the blood. These …

The diversity, architecture, and dynamics of the TCR repertoire largely determine our ability
to effectively withstand infections and malignancies with minimal mistargeting of immune …

The course of immune maturation has evolved to favour survival at each stage of
development in early life. Fetal and neonatal immune adaptations facilitate intrauterine …

For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it
has become increasingly evident that T cell-mediated immunity plays a central role in …