Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications

D Salvemini, SF Kim, V Mollace - American Journal of …, 2013 - journals.physiology.org
The nitric oxide (NO) and cyclooxygenase (COX) pathways share a number of similarities.
Nitric oxide is the mediator generated from the NO synthase (NOS) pathway, and COX …

Nitric oxide synthase and cyclooxygenase pathways: a complex interplay in cellular signaling

A Sorokin - Current Medicinal Chemistry, 2016 - ingentaconnect.com
The cellular reaction to external challenges is a tightly regulated process consisting of
integrated processes mediated by a variety of signaling molecules, generated as a result of …

[HTML][HTML] Antioxidant, antibacterial, anti-inflammatory, and anticancer properties of Cinnamomum kanehirae Hayata leaves extracts

PH Li, YJ Shih, WC Lu, PH Huang… - Arabian Journal of …, 2023 - Elsevier
Abstract Bull Camphor tree (Cinnamomum kanehirae Hayata; CKH)(Lauraceae) is an
endemic species in Taiwan. Its trunk is the main host of Taieanofugus camphoratus …

Nimbolide exerts protective effects in complete Freund's adjuvant induced inflammatory arthritis via abrogation of STAT-3/NF-κB/Notch-1 signaling

P Anchi, V Swamy, C Godugu - Life Sciences, 2021 - Elsevier
Abstract Aim Activation of transmembrane Notch-1 receptors through inflammatory cytokines
is highly regulated by STAT-3 and NF-κB phosphorylation. Nimbolide (NMB) exhibits potent …

Silymarin and celecoxib ameliorate experimental varicocele-induced pathogenesis: evidences for oxidative stress and inflammation inhibition

S Mazhari, M Razi, R Sadrkhanlou - International urology and nephrology, 2018 - Springer
Background The present study was done to investigate the ameliorative effect of silymarin
(SMN) and celecoxib (CEL) on varicocele (VCL)-induced detrimental impact in testicular …

iNOS signaling interacts with COX-2 pathway in colonic fibroblasts

Y Zhu, M Zhu, P Lance - Experimental cell research, 2012 - Elsevier
COX-2 and iNOS are two major inflammatory mediators implicated in colorectal
inflammation and cancer. Previously, the role of colorectal fibroblasts involved in regulation …

Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish

SH Cha, Y Hwang, KN Kim, HS Jun - Fish & shellfish immunology, 2018 - Elsevier
Inflammation markers in zebrafish embryos reflect a toxic response that is common to other
animal models and humans. Free fatty acids (FFAs) are known to cause damage in various …

[HTML][HTML] Mycotoxin zearalenone attenuates innate immune responses and suppresses NLRP3 inflammasome activation in LPS-activated macrophages

PY Lee, CC Liu, SC Wang, KY Chen, TC Lin, PL Liu… - Toxins, 2021 - mdpi.com
Zearalenone (ZEA) is a mycotoxin that has several adverse effects on most mammalian
species. However, the effects of ZEA on macrophage-mediated innate immunity during …

Influence of nitric oxide signaling mechanisms in cancer

R Ramírez-Patiño, G Avalos-Navarro… - International …, 2022 - journals.sagepub.com
Nitric oxide (NO) is a molecule with multiple biological functions that is involved in various
pathophysiological processes such as neurotransmission and blood vessel relaxation as …

[HTML][HTML] Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update

RI Jaén, P Prieto, M Casado… - World journal of …, 2018 - ncbi.nlm.nih.gov
The biosynthesis of prostanoids is involved in both physiological and pathological
processes. The expression of prostaglandin-endoperoxide synthase 2 (PTGS2; also known …