[HTML][HTML] Phase separation in biology; functional organization of a higher order
DM Mitrea, RW Kriwacki - Cell Communication and Signaling, 2016 - Springer
Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …
compartments and, within these, some are further organized into non-membrane-bounded …
AP-1—the Jun proteins: oncogenes or tumor suppressors in disguise?
E Shaulian - Cellular signalling, 2010 - Elsevier
Since its discovery more than two decades ago the involvement of the Activating protein 1
(AP-1) in proliferation, inflammation, differentiation, apoptosis, cellular migration and wound …
(AP-1) in proliferation, inflammation, differentiation, apoptosis, cellular migration and wound …
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
B Falini, I Nicoletti, MF Martelli, C Mecucci - Blood, 2007 - ashpublications.org
The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …
[HTML][HTML] Targeting the nucleolus for cancer intervention
The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …
Divorcing ARF and p53: an unsettled case
CJ Sherr - Nature Reviews Cancer, 2006 - nature.com
Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
The relationship between the nucleolus and cancer: Current evidence and emerging paradigms
The nucleolus is the most prominent nuclear substructure assigned to produce ribosomes;
molecular machines that are responsible for carrying out protein synthesis. To meet the …
molecular machines that are responsible for carrying out protein synthesis. To meet the …
[HTML][HTML] Nucleolus and nucleolar stress: from cell fate decision to disease development
Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …
Structural polymorphism in the N-terminal oligomerization domain of NPM1
Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome
biogenesis, tumor suppression, and nucleolar stress response. Here we show that the N …
biogenesis, tumor suppression, and nucleolar stress response. Here we show that the N …
Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias
Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phoshoprotein which shuttles
continuously between the nucleus and cytoplasm. Many findings have revealed a complex …
continuously between the nucleus and cytoplasm. Many findings have revealed a complex …