Genomics of disease risk in globally diverse populations

D Gurdasani, I Barroso, E Zeggini… - Nature Reviews …, 2019 - nature.com
Risk of disease is multifactorial and can be shaped by socio-economic, demographic,
cultural, environmental and genetic factors. Our understanding of the genetic determinants …

Polygenic scores in cancer

X Yang, S Kar, AC Antoniou, PDP Pharoah - Nature reviews Cancer, 2023 - nature.com
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …

[HTML][HTML] Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

F Madia, A Worth, M Whelan, R Corvi - Environment international, 2019 - Elsevier
Cancer is a key public health concern, being the second leading cause of worldwide
morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence …

[HTML][HTML] A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999–2014

VK Nguyen, A Kahana, J Heidt, K Polemi… - Environment …, 2020 - Elsevier
Background Stark racial disparities in disease incidence among American women remain a
persistent public health challenge. These disparities likely result from complex interactions …

[HTML][HTML] Clinical and molecular aspects of breast cancer: Targets and therapies

RLN Godone, GM Leitão, NB Araújo… - Biomedicine & …, 2018 - Elsevier
Breast Cancer is a complex disease characterized by the occurrence of multiple molecular
alterations. Currently, some molecular markers are in use for breast cancer diagnostic …

Living with metastatic cancer: a roadmap for future research

DB Tometich, KA Hyland, H Soliman, HSL Jim… - Cancers, 2020 - mdpi.com
Simple Summary Although people with metastatic cancer are living longer with their
disease, they are faced with challenges that can interfere with their quality of life. These …

The contribution of genomic research to explaining racial disparities in cardiovascular disease: a systematic review

JS Kaufman, L Dolman, D Rushani… - American journal of …, 2015 - academic.oup.com
After nearly a decade of genome-wide association studies, no assessment has yet been
made of their contribution toward an explanation of the most prominent racial health …

[HTML][HTML] Challenges of deciphering gastric cancer heterogeneity

P Hudler - World Journal of Gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Gastric cancer is in decline in most developed countries; however, it still accounts for a
notable fraction of global mortality and morbidity related to cancer. High-throughput methods …

[HTML][HTML] Role of vitamin D in head and neck cancer—Immune function, anti-tumour effect, and its impact on patient prognosis

K Starska-Kowarska - Nutrients, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) describes a heterogeneous group of
human neoplasms of the head and neck with high rates of morbidity and mortality …

[HTML][HTML] Histological classification, grading, staging, and prognostic indexing of female breast cancer in an African population: A 10-year retrospective study

WA Oluogun, KA Adedokun, MA Oyenike… - … journal of health …, 2019 - ncbi.nlm.nih.gov
Background: Breast cancer (BC) is a heterogeneous disease characterized with diverse
genetic and ethnic/racial variations that may influence tumor characteristics and prognosis …