Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis
are involved in the development of sepsis and sepsis-induced cardiomyopathy (SIC) …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …