Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Objective: Research suggests that Puerarin may protect against sepsis-induced myocardial
damage. However, the mechanisms responsible for Puerarin's cardioprotective effect remain …

Importance Sepsis is considered to induce immune suppression, leading to increased
susceptibility to secondary infections with associated late mortality. Objective To determine …

Sepsis is characterized by a dysregulated inflammatory response to infection. Despite
studies in mice, the cellular and molecular basis of human sepsis remains unclear and …

The endothelium provides an essential and selective membrane barrier that regulates the
movement of water, solutes, gases, macromolecules and the cellular elements of the blood …

The nervous and immune systems have evolved in parallel from the early bilaterians, in
which innate immunity and a central nervous system (CNS) coexisted for the first time, to …

Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host
reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a …

Sepsis is a dynamic state that progresses at variable rates and has life-threatening
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of …

Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in
host defense and the return to homeostasis. Resolvin (Rv) D2 is a potent immunoresolvent …