The global prevalence of neurologic disorders is rising, and yet we are still unable to deliver
most drug molecules, in therapeutic quantities, to the brain. The blood brain barrier consists …

Lyophilization has been used to improve the long-term stability of polymeric nanoparticles
for drug delivery applications, avoiding their instability in suspension. However, this …

This paper describes the basic concepts for the transmucosal delivery of drugs, and in
particular the use of the nasal route for delivery of challenging drugs such as polar low …

The efficient and safe delivery of therapeutic proteins is the key to commercial success and,
in some cases, the demonstration of efficacy in current and future biotechnology products …

Over recent years the research focus within the field of respiratory drug delivery has
broadened to include a wide range of potential applications for inhalation by delivering …

In primary or metastatic lung cancer, administration of chemotherapeutic agents via
inhalation could increase exposure of lung tumor to the drug, while minimizing systemic side …

Formulation of proteins/peptides for therapeutic uses has often posed some challenges to
drug formulators. The main problem is the relatively weak forces involved in the native …

Chitosan is employed as an absorption enhancer for drug delivery strategies. Aim of this
study was to investigate the rapid effects on barrier properties of the intestinal epithelial cell …

Background: Respiratory diseases are mainly derived from acute and chronic inflammation
of the alveoli and bronchi. The pathophysiological mechanisms of pulmonary inflammation …

Chitosan is a biocompatible polysaccharide of natural origin that can act as a permeation
enhancer. In this study, we used an integral in vitro/in vivo correlation approach to: a) …