[HTML][HTML] Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

P Czarny, P Wigner, P Galecki, T Sliwinski - Progress in Neuro …, 2018 - Elsevier
A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

Depression in older adults

A Fiske, JL Wetherell, M Gatz - Annual review of clinical …, 2009 - annualreviews.org
Depression is less prevalent among older adults than among younger adults, but it can have
serious consequences. More than half of cases represent a first onset in later life. Although …

Parkinson's disease: clinical features and diagnosis

J Jankovic - Journal of neurology, neurosurgery & psychiatry, 2008 - jnnp.bmj.com
Objective: Parkinson's disease (PD) is a progressive neurological disorder characterised by
a large number of motor and non-motor features that can impact on function to a variable …

Depression and Parkinson's disease: current knowledge

L Marsh - Current neurology and neuroscience reports, 2013 - Springer
Depressive disturbances are common in patients with Parkinson's disease (PD) and
influence many other clinical aspects of the disease. In addition to causing inherent …

Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

D Weintraub, T Simuni, C Caspell‐Garcia… - Movement …, 2015 - Wiley Online Library
This study was undertaken to determine the prevalence and correlates of cognitive
impairment (CI) and neuropsychiatric symptoms (NPS) in early, untreated patients with …

[HTML][HTML] Baicalein alleviates depression-like behavior in rotenone-induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway

X Zhao, D Kong, Q Zhou, G Wei, J Song, Y Liang… - Biomedicine & …, 2021 - Elsevier
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder in the world. In addition to motor symptoms, a variety of non-motor symptoms …

Current approaches to the treatment of Parkinson's disease

J Jankovic, LG Aguilar - Neuropsychiatric disease and treatment, 2008 - Taylor & Francis
Enormous progress has been made in the treatment of Parkinson's disease (PD). As a result
of advances in experimental therapeutics, many promising therapies for PD are emerging …

A controlled trial of antidepressants in patients with Parkinson disease and depression

M Menza, RD Dobkin, H Marin, MH Mark, M Gara… - Neurology, 2009 - AAN Enterprises
Background: Parkinson disease (PD) is a common neurodegenerative disease affecting up
to 1 million individuals in the United States. Depression affects up to 50% of these patients …

Telephone-based cognitive behavioral therapy for depression in Parkinson disease: a randomized controlled trial

RD Dobkin, SL Mann, MA Gara, A Interian… - Neurology, 2020 - AAN Enterprises
Objective To determine whether, for patients with depression and Parkinson disease (PD),
telephone-based cognitive-behavioral treatment (T-CBT) alleviates depressive symptoms …