Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …

MECP2 duplication syndrome (MDS) is a rare, X-linked, neurodevelopmental disorder
caused by a duplication of the methyl-CpG-binding protein 2 (MECP2) gene—a gene in …

The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the
border territory at their intersection harboring neural crest and cranial placode progenitors …

Hirschsprung disease (HSCR) is the leading cause of neonatal functional intestinal
obstruction. It is a rare congenital disease with an incidence of one in 3,500–5,000 live …

Hirschsprung's disease is a neurocristopathy, caused by defective migration, proliferation,
differentiation and survival of neural crest cells, leading to gut aganglionosis. It usually …

Embryonic neural crest cells travel in discrete streams to precise locations throughout the
head and body. We previously showed that cranial neural crest cells respond …

The neural crest is regionalized along the anteroposterior axis, as demonstrated by
foundational lineage-tracing experiments that showed the restricted developmental potential …

Hirschsprung disease (HSCR, intestinal aganglionosis) is a multigenic disorder with
variable penetrance and severity that has a general population incidence of 1/5000 live …

Neural crest cells (NCCs) are a population of multipotent cells that migrate extensively
during vertebrate development. Alterations to neural crest ontogenesis cause several …

On the occasion of the 100th anniversary of Dr. Harald Hirschsprung's death, there is a
worldwide significant research effort toward identifying and understanding the role of genes …