Neuroblastoma: molecular pathogenesis and therapy

CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …

[HTML][HTML] A brief history of MECP2 duplication syndrome: 20-years of clinical understanding

D Ta, J Downs, G Baynam, A Wilson… - Orphanet Journal of …, 2022 - Springer
MECP2 duplication syndrome (MDS) is a rare, X-linked, neurodevelopmental disorder
caused by a duplication of the methyl-CpG-binding protein 2 (MECP2) gene—a gene in …

Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

RM Williams, M Lukoseviciute, T Sauka-Spengler… - Elife, 2022 - elifesciences.org
The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the
border territory at their intersection harboring neural crest and cranial placode progenitors …

[HTML][HTML] The emerging genetic landscape of Hirschsprung disease and its potential clinical applications

A Karim, CSM Tang, PKH Tam - Frontiers in Pediatrics, 2021 - frontiersin.org
Hirschsprung disease (HSCR) is the leading cause of neonatal functional intestinal
obstruction. It is a rare congenital disease with an incidence of one in 3,500–5,000 live …

[HTML][HTML] Hirschsprung's disease—recent understanding of embryonic aspects, etiopathogenesis and future treatment avenues

M Klein, I Varga - Medicina, 2020 - mdpi.com
Hirschsprung's disease is a neurocristopathy, caused by defective migration, proliferation,
differentiation and survival of neural crest cells, leading to gut aganglionosis. It usually …

[HTML][HTML] VEGF signals induce trailblazer cell identity that drives neural crest migration

R McLennan, LJ Schumacher, JA Morrison… - Developmental …, 2015 - Elsevier
Embryonic neural crest cells travel in discrete streams to precise locations throughout the
head and body. We previously showed that cranial neural crest cells respond …

From head to tail: regionalization of the neural crest

M Rocha, A Beiriger, EE Kushkowski… - …, 2020 - journals.biologists.com
The neural crest is regionalized along the anteroposterior axis, as demonstrated by
foundational lineage-tracing experiments that showed the restricted developmental potential …

[HTML][HTML] Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: old and new players

N Bondurand, EM Southard-Smith - Developmental biology, 2016 - Elsevier
Hirschsprung disease (HSCR, intestinal aganglionosis) is a multigenic disorder with
variable penetrance and severity that has a general population incidence of 1/5000 live …

[HTML][HTML] How tissue mechanical properties affect enteric neural crest cell migration

NR Chevalier, E Gazquez, L Bidault, T Guilbert… - Scientific reports, 2016 - nature.com
Neural crest cells (NCCs) are a population of multipotent cells that migrate extensively
during vertebrate development. Alterations to neural crest ontogenesis cause several …

[HTML][HTML] Hirschsprung's disease: clinical dysmorphology, genes, micro-RNAs, and future perspectives

CM Sergi, O Caluseriu, H McColl, DD Eisenstat - Pediatric research, 2017 - nature.com
On the occasion of the 100th anniversary of Dr. Harald Hirschsprung's death, there is a
worldwide significant research effort toward identifying and understanding the role of genes …