α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide …

DJ Li, F Huang, M Ni, H Fu, LS Zhang… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has
been reported to be involved in hypertension end-organ damage. In this study, we tested the …

Aortic aneurysms

H Lu, A Daugherty - Arteriosclerosis, Thrombosis, and Vascular …, 2017 - Am Heart Assoc
e60 Arterioscler Thromb Vasc Biol June 2017 also one important feature of asthma. A recent
study reported an association between active asthma and AAA in humans. 15 This group …

Pharmacotherapy in clinical trials for abdominal aortic aneurysms: A systematic review and meta-analysis

Z Su, J Guo, Y Gu - Clinical and Applied Thrombosis …, 2022 - journals.sagepub.com
Objective There is no medical treatment proven to limit abdominal aortic aneurysm (AAA)
progression. This systematic review aimed to summarise available trial evidence on the …

Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm

K Yoshimura, N Morikage… - Current drug …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …

Pathophysiology of abdominal aortic aneurysm: Biomarkers and novel therapeutic targets

M Torres-Fonseca, M Galan, D Martinez-Lopez… - Clínica e Investigación …, 2019 - Elsevier
Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and
mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease …

Research advances in drug therapy for abdominal aortic aneurysms over the past five years: An updated narrative review

R Li, Y Liu, J Jiang - International Journal of Cardiology, 2023 - Elsevier
Background Abdominal aortic aneurysms (AAA) rupture can lead to patient death. Surgical
treatment is currently the optimal treatment for AAA with large diameter (≥ 50 mm). For AAA …

Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections

YH Shen, SA LeMaire - Current problems in surgery, 2017 - Elsevier
The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …

Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin‐Deficient Mice via Upregulation of Angiotensin (1–7)

K Karasaki, H Kokubo, B Bumdelger… - Journal of the …, 2023 - Am Heart Assoc
Background Angiotensin II type 1 receptor blockers (ARBs) have been shown to limit the
growth of abdominal aortic aneurysm (AAA), but their efficacy is controversial. This study …

MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice

X Shi, W Ma, Y Pan, Y Li, H Wang, S Pan, Y Tian… - Laboratory …, 2020 - nature.com
Abdominal aortic aneurysm (AAA) is a potential lethal disease that is defined by an
irreversible dilatation (> 50%) of the aorta. During AAA expansion, the aortic wall is often …

[HTML][HTML] Exploring drug re-purposing for treatment of abdominal aortic aneurysms: a systematic review and meta-analysis

JSS Kristensen, L Krasniqi, LM Obel… - European Journal of …, 2023 - Elsevier
Objective Large abdominal aortic aneurysms (AAAs) present a significant mortality risk.
While numerous medical interventions have been proposed, no drugs have convincingly …