Increasing evidences suggest that inflammation plays a key role in the pathogenesis of
stroke, a devastating disease second only to cardiac ischemia as a cause of death …

The expression of some proteins in the autophagy pathway declines with age, which may
impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a …

Microglia, the major population of brain‐resident macrophages, are now recognized as a
heterogeneous population comprising several cell subtypes with different (so far mostly …

Microglial activation plays a central role in poststroke inflammation and causes secondary
neuronal damage; however, it also contributes in debris clearance and chronic recovery …

Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …

Endocannabinoids are important regulators of neurotransmission and, acting on activated
microglia, they are postulated as neuroprotective agents. Endocannabinoid action is …

We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-
penetrable analog N-(2-(dimethylamino) ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2 …

Microglia and monocytes play a critical role in immune responses to cerebral ischemia.
Previous studies have demonstrated that interferon regulatory factor 4 (IRF4) and IRF5 direct …

Microglia, the main resident immune cells in the CNS, are thought to participate in the
pathogenesis of various neurological disorders. LPS and LPS+ IFNγ are stimuli that are …

Microglial activation often accompanies the plastic changes occurring in the brain of patients
with neurodegenerative diseases. A2A and A3 adenosine receptors have been proposed as …