Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

Recent findings have significantly expanded our understanding of the regulation of actin-
depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these …

Ubiquitously expressed β-actin and γ-actin isoforms play critical roles in most cellular
processes; however, their unique contributions are not well understood. We generated …

As atmospheric levels of CO2 increase, reef-building corals are under greater stress from
both increased sea surface temperatures and declining sea water pH. To date, most studies …

Human ESCs are the pluripotent precursor of the three embryonic germ layers. Human
ESCs exhibit basal-apical polarity, junctional complexes, integrin-dependent matrix …

In collaboration or competition with many other actin-binding proteins, the actin-
depolymerizing factor/cofilins integrate transmembrane signals to coordinate the spatial and …

Alternative splicing of mRNA precursors represents a key gene expression regulatory step
and permits the generation of distinct protein products with diverse functions. In a genome …

Cholesterol provided by low-or high-density lipoprotein is the precursor for biosynthesis of
progesterone. Once inside the cell, cholesterol can be used for steroidogenesis or esterified …

Extracellular matrix signals from the microenvironment regulate gene expression patterns
and cell behavior. Using a combination of experiments and geometric models, we …

Dephosphorylation (activation) of cofilin, an actin binding protein, is stimulated by initiators
of neuronal dysfunction and degeneration including oxidative stress, excitotoxic glutamate …