The canonical Wnt/β-catenin pathway is up-regulated in gliomas and involved in
proliferation, invasion, apoptosis, vasculogenesis and angiogenesis. Nuclear β-catenin …

Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of
embryonic development; however it also underlies several pathological conditions in man …

The extensive involvement of miRNAs in cancer pathobiology has opened avenues for drug
development based on oncomir inhibition. Dicer is the core enzyme in miRNA processing …

Glioma is regarded as the most prevalent malignant carcinoma of the central nervous
system. Thus, the development of new therapeutic strategies targeting glioma is of …

Embryonic lung development requires reciprocal endodermal-mesodermal interactions;
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …

MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of
18–25 nucleotides that regulate gene expression by binding to complementary binding sites …

Presence of a distinct population of cells that drives tumor progression supports the
hierarchical model of tumor development in Glioblastoma (GBM) and substantiates the …

HOTAIR is a negative prognostic factor and is overexpressed in multiple human cancers
including glioblastoma multiform (GBM). Survival analysis of Chinese Glioma Genome Atlas …

Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 of hepatocellular
carcinomas (HCC), and a significant number of these have mutations in the β-catenin gene …

Gastric cancer, a highly invasive and aggressive malignancy, is the third leading cause of
death from cancer worldwide. Genetic association studies have successfully revealed …