Three decades of research have established the CCCTC-binding factor (CTCF) as a
ubiquitously expressed chromatin organizing factor and master regulator of gene …

MicroRNA (miRNA) has the potential for cross-regulation and functional integration of
discrete biological processes during complex physiological events. Utilizing the common …

Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled
RNA processing. However, molecular details of such co-transcriptional mechanisms remain …

Dysregulation of DNA methylation and mRNA alternative cleavage and polyadenylation
(APA) are both prevalent in cancer and have been studied as independent processes. We …

Rapid phenotypic changes in traits of adaptive significance are crucial for organisms to
thrive in changing environments. How such phenotypic variation is achieved rapidly, despite …

Cleavage stimulation factor 64 kDa (CstF64) is an essential pre-mRNA 3′ processing factor
and an important regulator of alternative polyadenylation (APA). Here we characterized …

Recent studies have revealed widespread mRNA alternative polyadenylation (APA) in
eukaryotes and its dynamic spatial and temporal regulation. APA not only generates …

Abstract mRNA alternative polyadenylation (APA) plays a critical role in post‐transcriptional
gene control and is highly regulated during development and disease. However, the …

Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …