Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …

Traumatic brain injury (TBI), defined as an alteration in brain functions caused by an external
force, is responsible for high morbidity and mortality around the world. It is important to …

Background Neuroinflammation is an important secondary injury mechanism that has dual
beneficial and detrimental roles in the pathophysiology of traumatic brain injury (TBI) …

Intracerebral hemorrhage (ICH) is a major health concern, with high rates of mortality and
morbidity and no highly effective clinical interventions. Basic research in animal models of …

Acute brain dysfunction is a frequent condition in sepsis patients and is associated with
increased mortality and long-term neurocognitive consequences. Impaired memory and …

Despite recent encouraging pharmaceutical and technical breakthroughs in neurosurgical
critical care, traumatic brain injury (TBI)-related mortality and morbidity remain substantial …

The use of mouse models in traumatic brain injury (TBI) has several advantages compared
to other animal models including low cost of breeding, easy maintenance, and innovative …

Importance Statin use during hospitalization is associated with improved survival and a
better discharge disposition among patients with ischemic stroke. It is unclear whether …

Background Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized
by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by …

Objective To identify predictors of the severity of agitated behavior during inpatient traumatic
brain injury (TBI) rehabilitation. Design Prospective, longitudinal observational study. Setting …