Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential

S Hang, W Wu, Y Wang, R Sheng… - Chemistry & …, 2022 - Wiley Online Library
Coumarins is a huge family of phenolic compounds containing a common structure of 2H‐1‐
benzopyran‐2‐one. Nowadays, more than 1,300 natural‐based coumarins have been …

A review: Pharmacokinetics and pharmacology of aminoalcohol-diterpenoid alkaloids from Aconitum species

H Tao, X Liu, R Tian, Y Liu, Y Zeng, X Meng… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Aconitum medicinal materials, such as Aconitum
carmichaelii Debeaux (Chinese: Wutou/乌头) and Aconitum kusnezoffii Reichb.(Chinese …

Divergent Total Syntheses of Napelline-Type C20-Diterpenoid Alkaloids:(−)-Napelline,(+)-Dehydronapelline,(−)-Songorine,(−)-Songoramine,(−)-Acoapetaldine D, and …

S Jin, X Zhao, D Ma - Journal of the American Chemical Society, 2022 - ACS Publications
The napelline-type alkaloids possess an azabicyclo [3.2. 1] octane moiety and an ent-
kaurane-type tetracyclic skeleton (6/6/6/5) along with varied oxidation patterns embedded in …

Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors

Z Fu, L Zhang, S Hang, S Wang, N Li, X Sun, Z Wang… - Polymers, 2022 - mdpi.com
To expand the range of daphnetin-based inhibitors/activators used for targeting G protein-
coupled receptors (GPCRs) in disease treatment, twenty-five coumarin derivatives 1–25 …

Synthesis and bioactivities of marine pyran-isoindolone derivatives as potential antithrombotic agents

Y Wang, H Chen, R Sheng, Z Fu, J Fan, W Wu, Q Tu… - Marine Drugs, 2021 - mdpi.com
2, 5-Bis-[8-(4, 8-dimethyl-nona-3, 7-dienyl)-5, 7-dihydroxy-8-methyl-3-keto-1, 2, 7, 8-
teraahydro-6 H-pyran [a] isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran …

Syntheses and evaluation of daphnetin derivatives as novel G protein-coupled receptor inhibitors and activators

Y Wang, J Wang, Z Fu, R Sheng, W Wu, J Fan… - Bioorganic …, 2020 - Elsevier
Abstract A series of daphnetin (7, 8-dihydroxycoumarin) derivatives 1–22 were synthesized
including sixteen new compounds (1–5, 7–14, 18, 21 and 22) and six known compounds (6 …

Total Synthesis of Liangshanone

HX Huang, F Mi, C Li, H He, FP Wang… - Angewandte Chemie …, 2020 - Wiley Online Library
The first total synthesis of liangshanone, a hexacyclic ent‐kaurane diterpenoid alkaloid, has
been completed. Its intricate cagelike framework was assembled through several key …

Simultaneous determination of five bioactive components of XiaoJin Capsule in normal and mammary gland hyperplasia rat plasma using LC–MS/MS and its …

X Wang, H Lei, X Qi, X Guo, X Xu… - Biomedical …, 2021 - Wiley Online Library
XiaoJin Capsule (XJC) is a classic Traditional Chinese Medicine formula for clinical
treatment of thyroid nodules, mammary gland hyperplasia and breast cancer. For the …

雪上一枝蒿化学成分及其生物活性的研究进展.

韦鹏威, 杨宇婷, 王聪, 刘红美… - Chinese Journal of …, 2022 - search.ebscohost.com
雪上一枝蒿为云南, 四川等地民间常用药材, 被用于治疗风湿疼痛, 跌打损伤等症,
主要成分为生物碱. 其毒性剧烈, 但在镇痛方面有显著疗效, 具有重要的药用价值 …

Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors

GN Zyuz'kov, EA Losev, NI Suslov… - Bulletin of Experimental …, 2024 - Springer
We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP,
ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular signaling in the …