The importance of the RET gene in thyroid cancer and therapeutic implications
D Salvatore, M Santoro, M Schlumberger - Nature Reviews …, 2021 - nature.com
Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein
have been found in diverse thyroid cancer subtypes. RET gene rearrangements are …
have been found in diverse thyroid cancer subtypes. RET gene rearrangements are …
Thyroid cancer incidence trends by histology in 25 countries: a population-based study
A Miranda-Filho, J Lortet-Tieulent, F Bray… - The lancet Diabetes & …, 2021 - thelancet.com
Background The incidence of thyroid cancer has increased in different populations
worldwide in the past 30 years. We present here an overview of international trends of …
worldwide in the past 30 years. We present here an overview of international trends of …
GLOBAL ENDOCRINOLOGY: Geographical variation in the profile of RET variants in patients with medullary thyroid cancer: a comprehensive review
RMB Maciel, AL Maia - European Journal of Endocrinology, 2022 - academic.oup.com
Genetic variability in humans is influenced by many factors, such as natural selection,
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …
The changing face of multiple endocrine neoplasia 2A: from symptom-based to preventative medicine
A Machens, K Lorenz, T Brandenburg… - The Journal of …, 2023 - academic.oup.com
Context Early genetic association studies yielded too high risk estimates for multiple
endocrine neoplasia (MEN2A), suggesting a need for extended surgery. Objective The …
endocrine neoplasia (MEN2A), suggesting a need for extended surgery. Objective The …
Prediction of biochemical cure in patients with medullary thyroid cancer
A Machens, K Lorenz, H Dralle - Journal of British Surgery, 2020 - academic.oup.com
Background The impact of number of node metastases versus metastatic lymph node ratio
versus AJCC node category on biochemical cure in medullary thyroid cancer (MTC) is not …
versus AJCC node category on biochemical cure in medullary thyroid cancer (MTC) is not …
[HTML][HTML] Prognostic value of preoperative serum calcitonin levels for predicting the recurrence of medullary thyroid carcinoma
H Park, SY Park, J Park, JH Choe, MK Chung… - Frontiers in …, 2021 - frontiersin.org
Background Serum calcitonin level is a useful biomarker for predicting primary tumor size,
the extent of lymph node, and distant metastasis in patients with medullary thyroid …
the extent of lymph node, and distant metastasis in patients with medullary thyroid …
Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997–2014: a nationwide study
JS Mathiesen, JP Kroustrup, P Vestergaard… - Thyroid, 2019 - liebertpub.com
Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the
general population is poorly described. Data on the factors predicting long-term biochemical …
general population is poorly described. Data on the factors predicting long-term biochemical …
Exceptionality of distant metastasis in node-negative hereditary and sporadic medullary thyroid cancer: lessons learned
A Machens, K Lorenz, F Weber… - The Journal of Clinical …, 2021 - academic.oup.com
Context Risk factors of lymph node and distant metastases have rarely been analyzed in
hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data …
hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data …
Germline founder variant c.1998delinsTTCT in the RET oncogene: a cohort study in 15 Belgian families
A Vuylsteke, L Hannes, H Brems, K Devis… - European Journal of …, 2023 - academic.oup.com
Objective The c. 1998delinsTTCT variant in the RET gene (codon 666) is linked to medullary
thyroid carcinoma in Belgium. We aimed to study the clinical phenotype and the age …
thyroid carcinoma in Belgium. We aimed to study the clinical phenotype and the age …
[HTML][HTML] Trends in the diagnosis and treatment of patients with medullary thyroid carcinoma in Korea
HY Ahn, JE Chae, H Moon, J Noh… - Endocrinology and …, 2020 - synapse.koreamed.org
Background Thyroid cancer is becoming increasingly common worldwide, but little is known
about the epidemiology of medullary thyroid carcinoma (MTC). This study investigated the …
about the epidemiology of medullary thyroid carcinoma (MTC). This study investigated the …