Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Functional precision medicine is a strategy whereby live tumor cells from affected individuals
are directly perturbed with drugs to provide immediately translatable, personalized …

Numerous studies are exploring the use of cell adoptive therapies to treat hematological
malignancies as well as solid tumors. However, there are numerous factors that dampen the …

Circulating tumor cell (CTC) clusters that are shed from the primary tumor into the
bloodstream are associated with a poor prognosis, elevated metastatic potential, higher …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …

One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …

Background In head and neck cancer, intratumour lymphatic density and tumour
lymphangiogenesis have been correlated with lymphatic metastasis, making …

Precision medicine approaches that inform clinical management of individuals with cancer
are progressively advancing. Patient-derived explants (PDEs) provide a patient-proximal ex …

Modeling renal cell carcinoma is critical to investigating tumor biology and therapeutic
mechanisms. Multiple systems have been developed to represent critical components of the …