Over the last decade there has been an enormous expansion of research focused on
defining the role of inflammation in aging, age-related diseases, disability, and frailty. The …

This chapter examines the current state of research on frailty. A number of competing and
complementary models for its development are described, followed by a working definition …

Objective To examine the association of serum concentrations of 25‐hydroxyvitamin D [25
(OH) D], interleukin‐6 (IL‐6), C‐reactive protein (CRP) and IGF‐1 with prevalent and …

Muscle mass and strength are well known to decline in response to actual and simulated
microgravity exposure. However, despite the considerable knowledge gained on the …

Anemia is currently defined by the World Health Organization (WHO) as a hemoglobin (Hb)
level< 13 g/dL in men and< 12 g/dL in women. While estimates vary widely, nearly one …

The inflammation of aging hypothesis purports that aging is the accumulation of damage,
which results, in part, from chronic activation of inflammation process. We tested this …

Background: The role of magnesium in maintaining muscle integrity and function in older
adults is largely unknown. Objective: We aimed to investigate the relation between serum …

Muscle damage with a lack of regeneration, manifests itself in several life-threatening
diseases, including cancer cachexia, congestive heart failure, AIDS and sepsis. Often …

Interleukin-6 is a pleiotropic cytokine which plays a crucial role in immune physiology and is
tightly controlled by hormonal feedback mechanisms. After menopause or andropause, loss …

Objectives: To examine whether low serum albumin is associated with low muscle strength
and future decline in muscle strength in community‐dwelling older men and women. Design …