The function and activity of a protein are often modulated by other proteins with which it
interacts. This review is intended as a practical guide to the analysis of such protein-protein …

Recent structural and biophysical results have provided unprecedented insights into the
structure and function of the bacterial RNA polymerase holoenzyme as it goes through the …

Species of RNA that bind with high affinity and specificity to the bronchodilator theophylline
were identified by selection from an oligonucleotide library. One RNA molecule binds to …

Thrombin, a multifunctional serine protease, recognizes multiple macromolecular substrates
and plays a key role in both procoagulant and anticoagulant functions. The substrate …

Vascular endothelial growth factor (VEGF) has been implicated in the pathological induction
of new blood vessel growth in a variety of proliferative disorders. Using the SELEX process …

Using single-molecule DNA nanomanipulation, we show that abortive initiation involves
DNA “scrunching”—in which RNA polymerase (RNAP) remains stationary and unwinds and …

Seven different species of the RNA polymerase σ subunit exist in Escherichia coli, each
binding to a single species of the core enzyme and thereby directing transcription of a …

Intrinsic termination of transcription in Escherichia coli involves the formation of an RNA
hairpin in the nascent RNA. This hairpin plays a central role in the release of the transcript …

Physiological changes that result in changes in bacterial gene expression are often
accompanied by changes in the growth rate for fast adapting enteric bacteria. Because the …

A list of currently identified gene products of Escherichia coli is given, together with a
bibliography that provides pointers to the literature on each gene product. A scheme to …