Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

MA Waszczuk, KG Jonas, M Bornovalova, G Breen… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

Genetic architecture of subcortical brain structures in 38,851 individuals

CL Satizabal, HHH Adams, DP Hibar, CC White… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …

[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …

TGM Van Erp, E Walton, DP Hibar, L Schmaal… - Biological …, 2018 - Elsevier
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

Brain circuitry of compulsivity

OA Van den Heuvel, G van Wingen… - European …, 2016 - Elsevier
Compulsivity is associated with alterations in the structure and the function of parallel and
interacting brain circuits involved in emotional processing (involving both the reward and the …

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

L Schmaal, E Pozzi, T C. Ho, LS Van Velzen… - Translational …, 2020 - nature.com
A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

Functional connectomics in depression: insights into therapies

Y Chai, YI Sheline, DJ Oathes, NL Balderston… - Trends in Cognitive …, 2023 - cell.com
Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

[HTML][HTML] Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies

L Nyberg, CJ Boraxbekk, DE Sörman, P Hansson… - Ageing research …, 2020 - Elsevier
Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others …

JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps

J Dukart, S Holiga, M Rullmann, R Lanzenberger… - 2021 - Wiley Online Library
Recent studies have shown that druginduced spatial alteration patterns in resting state
functional activity as measured using magnetic resonance imaging (rsfMRI) are associated …

Machine learning approaches for clinical psychology and psychiatry

DB Dwyer, P Falkai… - Annual review of clinical …, 2018 - annualreviews.org
Machine learning approaches for clinical psychology and psychiatry explicitly focus on
learning statistical functions from multidimensional data sets to make generalizable …

Prediction complements explanation in understanding the developing brain

MD Rosenberg, BJ Casey, AJ Holmes - Nature communications, 2018 - nature.com
A central aim of human neuroscience is understanding the neurobiology of cognition and
behavior. Although we have made significant progress towards this goal, reliance on group …