The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …
Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism
A number of studies have reported that zinc plays a substantial role in the development of
metabolic syndrome, taking part in the regulation of cytokine expression, suppressing …
metabolic syndrome, taking part in the regulation of cytokine expression, suppressing …
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …
Oxidative stress and inflammation in COVID-19-associated sepsis: the potential role of anti-oxidant therapy in avoiding disease progression
J Beltrán-García, R Osca-Verdegal, FV Pallardó… - Antioxidants, 2020 - mdpi.com
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
emerged, countless efforts are being made worldwide to understand the molecular …
emerged, countless efforts are being made worldwide to understand the molecular …
[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …
microbial pathogens, irritants, or toxic cellular components. The primary physical …
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other
metabolic diseases is well documented. However, a possible physiological role for IL-1β in …
metabolic diseases is well documented. However, a possible physiological role for IL-1β in …
Beta cell dysfunction and insulin resistance
ME Cerf - Frontiers in endocrinology, 2013 - frontiersin.org
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …
[HTML][HTML] Inflammatory links between obesity and metabolic disease
CN Lumeng, AR Saltiel - The Journal of clinical …, 2011 - Am Soc Clin Investig
The obesity epidemic has forced us to evaluate the role of inflammation in the health
complications of obesity. This has led to a convergence of the fields of immunology and …
complications of obesity. This has led to a convergence of the fields of immunology and …
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
H Khodabandehloo, S Gorgani-Firuzjaee… - Translational …, 2016 - Elsevier
Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …
Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties
E Teixeira-Lemos, S Nunes, F Teixeira… - Cardiovascular diabetology, 2011 - Springer
Diabetes mellitus has emerged as one of the main alarms to human health in the 21st
century. Pronounced changes in the human environment, behavior and lifestyle have …
century. Pronounced changes in the human environment, behavior and lifestyle have …