Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …

Transforming growth factor (TGF)-β is an evolutionarily conserved pleiotropic factor that
regulates a myriad of biological processes including development, tissue regeneration …

Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered
the development of disease-modifying therapy. The functional relationship between …

(Myo) fibroblasts are key players for maintaining skin homeostasis and for orchestrating
physiological tissue repair.(Myo) fibroblasts are embedded in a sophisticated extracellular …