Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats

C Cui, X Xiong, J Zhao, D Fu, Y Zhang, P Ma… - Acta Pharmacologica …, 2024 - nature.com
Mechanosensitive cation channels such as Piezo1 and Piezo2 are activated by mechanical
force like a starched wall of the aorta while blood pressure (BP) rising, which helps to …

The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions

Y Li, Y Feng, L Liu, X Li, X Li, X Sun, K Li… - Acta Pharmacologica …, 2021 - nature.com
Abstract Hydrogen sulfide (H2S), which is closely related to various cardiovascular
disorders, lowers blood pressure (BP), but whether this action is mediated via the …

A second wave for the neurokinin Tac2 pathway in brain research

AS Al Abed, NJ Reynolds, N Dehorter - Biological Psychiatry, 2021 - Elsevier
Despite promising advances in basic research of the neurokinin B/Tac2 pathway in both
animals and humans, clinical applications are yet to be implemented. This is likely because …

FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function

P Chen, B Xu, Y Feng, KX Li, Z Liu, X Sun, XL Lu… - Brain Research …, 2020 - Elsevier
Hypertension is a common complication of metabolic abnormalities associated with
cardiovascular system and characterized by sexual dimorphism in mammals. Fibroblast …

Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Y Fan, R Zha, T Sano, X Zhao, S Liu, MD Woollam… - Bone Research, 2021 - nature.com
Mechanical loading to the bone is known to be beneficial for bone homeostasis and for
suppressing tumor-induced osteolysis in the loaded bone. However, whether loading to a …

Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats

K Naitou, H Iwashita, HH Ueda… - American Journal …, 2022 - journals.physiology.org
Noxious stimuli on the colorectum cause colorectal contractions through activation of
descending monoaminergic pathways projecting from the supraspinal defecation center to …

Estrogen-dependent KCa1. 1 modulation is essential for retaining neuroexcitation of female-specific subpopulation of myelinated Ah-type baroreceptor neurons in rats

L Wang, Z Qian, H Ma, M Zhou, H Li, C Cui… - Acta Pharmacologica …, 2021 - nature.com
Female-specific subpopulation of myelinated Ah-type baroreceptor neurons (BRNs) in
nodose ganglia is the neuroanatomical base of sexual-dimorphic autonomic control of blood …

Bradykinin‐mediated estrogen‐dependent depressor response by direct activation of female‐specific distribution of myelinated Ah‐type baroreceptor neurons in rats

KX Li, Y Feng, XX Fan, X Sun, Y Li… - CNS Neuroscience …, 2022 - Wiley Online Library
Aim To understand the direct impact of bradykinin in autonomic control of circulation through
baroreflex afferent pathway. Methods The mean arterial pressure (MAP) was monitored …