Ammonia toxicity: from head to toe?
S Dasarathy, RP Mookerjee, V Rackayova… - Metabolic brain …, 2017 - Springer
Ammonia is diffused and transported across all plasma membranes. This entails that
hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that …
hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that …
[HTML][HTML] Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure
M Romero-Gómez, S Montagnese, R Jalan - Journal of Hepatology, 2015 - Elsevier
Hepatic encephalopathy in a hospitalized cirrhotic patient is associated with a high mortality
rate and its presence adds further to the mortality of patients with acute-on-chronic liver …
rate and its presence adds further to the mortality of patients with acute-on-chronic liver …
Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy
BACKGROUND & AIMS: Hyperammonemia and inflammation cooperate to induce
neurological alterations in hepatic encephalopathy. Recent studies in animal models …
neurological alterations in hepatic encephalopathy. Recent studies in animal models …
[HTML][HTML] Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats
R Valladares, D Sankar, N Li, E Williams, KK Lai… - Plos one, 2010 - journals.plos.org
Background The intestinal epithelium is a barrier that composes one of the most
immunologically active surfaces of the body due to constant exposure to microorganisms as …
immunologically active surfaces of the body due to constant exposure to microorganisms as …
The liver–brain axis in liver failure: neuroinflammation and encephalopathy
RF Butterworth - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Systemic inflammation is common in liver failure and its acquisition is a predictor of hepatic
encephalopathy severity. New studies provide convincing evidence for a role of …
encephalopathy severity. New studies provide convincing evidence for a role of …
Hepatic encephalopathy: a central neuroinflammatory disorder?
RF Butterworth - Hepatology, 2011 - journals.lww.com
Encephalopathy and brain edema are serious central nervous system complications of liver
failure. Recent studies using molecular probes and antibodies to cell-specific marker …
failure. Recent studies using molecular probes and antibodies to cell-specific marker …
[HTML][HTML] Disturbance of the glutamate-glutamine cycle, secondary to hepatic damage, compromises memory function
ID Limón, I Angulo-Cruz, L Sánchez-Abdon… - Frontiers in …, 2021 - frontiersin.org
Glutamate fulfils many vital functions both at a peripheral level and in the central nervous
system (CNS). However, hyperammonemia and hepatic failure induce alterations in …
system (CNS). However, hyperammonemia and hepatic failure induce alterations in …
Hyperammonemia in inherited metabolic diseases
GS Ribas, FF Lopes, M Deon, CR Vargas - Cellular and Molecular …, 2022 - Springer
Ammonia is a neurotoxic compound which is detoxified through liver enzymes from urea
cycle. Several inherited or acquired conditions can elevate ammonia concentrations in …
cycle. Several inherited or acquired conditions can elevate ammonia concentrations in …
[PDF][PDF] Microglia activation in hepatic encephalopathy in rats and humans
I Zemtsova, B Görg, V Keitel, HJ Bidmon, K Schrör… - …, 2011 - Wiley Online Library
Astrocytes play an important role in the pathogenesis of hepatic encephalopathy (HE) and
ammonia toxicity, whereas little is known about microglia and neuroinflammation under …
ammonia toxicity, whereas little is known about microglia and neuroinflammation under …
[HTML][HTML] Cellular pathogenesis of hepatic encephalopathy: An update
K Lu - Biomolecules, 2023 - mdpi.com
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome derived from metabolic
disorders due to various liver failures. Clinically, HE is characterized by hyperammonemia …
disorders due to various liver failures. Clinically, HE is characterized by hyperammonemia …