Stroke is an important issue in public health due to its high rates both of morbidity and
mortality, and high rate of disability. Hypertension, cardiovascular disease, arterial …

The immune response following neuroinflammation is a vital element of ischemic stroke
pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that …

Background and Purpose—Inflammation is emerging as a key component of the
pathophysiology of intracranial aneurysms. Peroxisome proliferator–activated receptor-γ …

OBJECTIVE Aspirin has emerged as a potential agent in the prevention of rupture of
intracranial aneurysms (IAs). In this study, the authors' goal was to test if aspirin is protective …

OBJECTIVE Although aspirin usage may be associated with a decreased risk of rupture of
cerebral aneurysms, any potential therapeutic benefit from aspirin must be weighed against …

BACKGROUND: Epidemiological studies have indicated that postmenopausal women have
a higher incidence of intracranial aneurysms than men in the same age group. OBJECTIVE …

Cerebral aneurysms (CAs) have become a health burden not only because their rupture is
life threatening, but for a series of devastating complications left in survivors. It is well …

High blood levels of inflammatory biomarkers and immune cells in stroke lesions have been
recognized as results of stroke. However, recent studies have suggested that inflammation …

We have developed a mouse model of intracranial aneurysm that recapitulates key features
of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs …

The development of new treatment strategies for intracranial aneurysms (IAs) has been and
continues to be a major interest in neurovascular research. Initial treatment concepts were …