[HTML][HTML] Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs

AR Saniabadi, T Tanaka, T Ohmori… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

Granulomonocytapheresis as a cell‐dependent treatment option for patients with inflammatory bowel disease: concepts and clinical features for better therapeutic …

AR Saniabadi, T Tanaka, T Yamamoto… - Journal of clinical …, 2019 - Wiley Online Library
Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naive ulcerative colitis during active and quiescent disease

R Matsuda, T Koide, C Tokoro… - Inflammatory bowel …, 2009 - academic.oup.com
Background Cytokines have validated roles in the immunopathogenesis of inflammatory
bowel disease (IBD). This study was to investigate the expressions of tumor necrosis factor …

Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan

T Hibi, Y Sameshima, Y Sekiguchi, Y Hisatome… - Digestive and Liver …, 2009 - Elsevier
BACKGROUND/AIM: The Adacolumn selectively depletes granulocytes and monocytes/
macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis …

In patients with ulcerative colitis, adsorptive depletion of granulocytes and monocytes impacts mucosal level of neutrophils and clinically is most effective in steroid …

T Tanaka, H Okanobu, S Yoshimi, E Murakami… - Digestive and Liver …, 2008 - Elsevier
BACKGROUND.: The aetiology of ulcerative colitis is inadequately understood, and drug
therapy has been empirical rather than based on sound understanding of disease aetiology …

A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis

T Yamamoto, T Iida, K Ikeya, M Kato… - Clinical and …, 2018 - journals.lww.com
Objectives: Adsorptive granulomonocytapheresis (GMA) with the Adacolumn has been
introduced as a nonpharmacologic treatment for ulcerative colitis (UC). However, a subset of …

Mucosal healing in patients with ulcerative colitis during a course of selective leukocytapheresis therapy: a prospective cohort study

T Yamamoto, S Umegae… - Inflammatory bowel …, 2010 - academic.oup.com
Background During active ulcerative colitis (UC), vast numbers of granulocytes, monocytes/
macrophages (GM) infiltrate the mucosal tissue and can potentially exacerbate inflammation …

Looking for predictive factors of clinical response to adsorptive granulocyte and monocyte apheresis in patients with ulcerative colitis: markers of response to GMA

Y Yokoyama, M Kawai, K Fukunaga, K Kamikozuru… - BMC …, 2013 - Springer
Background Adsorptive granulocyte and monocyte apheresis (GMA) with an Adacolumn in
patients with ulcerative colitis (UC) has been applied as a non-pharmacological treatment …

Intensive granulocyte and monocyte adsorption versus intravenous prednisolone in patients with severe ulcerative colitis: an unblinded randomised multi-centre …

H Hanai, T Iida, K Takeuchi, F Watanabe… - Digestive and Liver …, 2008 - Elsevier
BACKGROUND AND AIM: Several uncontrolled studies have reported on the efficacy of
adsorptive depletion of peripheral blood granulocytes and monocytes/macrophages (GMA) …

Long-term clinical impact of early introduction of granulocyte and monocyte adsorptive apheresis in new onset, moderately active, extensive ulcerative colitis

T Yamamoto, S Umegae… - Journal of Crohn's and …, 2012 - academic.oup.com
Background and aims: The efficacy of granulocyte and monocyte adsorptive apheresis
(GMA) for patients with a first episode of ulcerative colitis (UC) has been scarcely reported …