High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid
organs, providing both a structural matrix and soluble factors that regulate survival and …

Immune checkpoint blockade therapies fail to induce responses in the majority of cancer
patients, so how to increase the objective response rate becomes an urgent challenge …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

Multiple sclerosis (MS) is characterized by synthesis of oligoclonal immunoglobulins and the
presence of B‐cell clonal expansions in the central nervous system (CNS). Because ectopic …

The frequent observation of organized lymphoid structures that resemble secondary
lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as …

Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer
(NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate …

Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally
a problem of concern only to immunologists. With the discovery of l-selectin and its ligands …

A synergistic combination of two next-generation sequencing platforms with a detailed
comparative BAC physical contig map provided a cost-effective assembly of the genome …

In rheumatoid arthritis (RA), tissue-infiltrating lymphocytes can be arranged in sophisticated
organizations that resemble microstructures usually formed in secondary lymphoid organs …