The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Transcriptional regulation by Polycomb group proteins
L Di Croce, K Helin - Nature structural & molecular biology, 2013 - nature.com
Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …
in stem-cell identity, differentiation and disease. Mechanistically, they function within …
[HTML][HTML] PRC1 catalytic activity is central to polycomb system function
The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …
expression. Despite being extensively studied, how the Polycomb system selects its target …
[HTML][HTML] Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …
play an essential role in gene regulation, cellular differentiation, and development. However …
A double take on bivalent promoters
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …
Regulation of gene transcription by Polycomb proteins
S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …
regulation during development. Recent studies suggest that Polycomb repressive …
[HTML][HTML] REST and neural gene network dysregulation in iPSC models of Alzheimer's disease
The molecular basis of the earliest neuronal changes that lead to Alzheimer's disease (AD)
is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene …
is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene …
[HTML][HTML] Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Histone posttranslational modifications are key regulators of chromatin-associated
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …
[HTML][HTML] A high-density map for navigating the human polycomb complexome
Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …