Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

[HTML][HTML] Treatment of spinal cord injury with mesenchymal stem cells

LL Liau, QH Looi, WC Chia, T Subramaniam, MH Ng… - Cell & bioscience, 2020 - Springer
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to
temporary or permanent loss of function due to injury to the nerve. The SCI patients are often …

[HTML][HTML] Acute spinal cord injury: Pathophysiology and pharmacological intervention

Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade

C Oyinbo - Acta neurobiologiae experimentalis, 2011 - ane.pl
The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary
mechanisms of injury. Though both mechanisms are involved in the neurological …

Targeting recovery: priorities of the spinal cord-injured population

KD Anderson - Journal of neurotrauma, 2004 - liebertpub.com
In the United States alone, there are more than 200,000 individuals living with a chronic
spinal cord injury (SCI). Healthcare for these individuals creates a significant economic …

Polymer scaffolds facilitate spinal cord injury repair

Q Zhang, B Shi, J Ding, L Yan, JP Thawani, C Fu… - Acta biomaterialia, 2019 - Elsevier
During the past decades, improving patient neurological recovery following spinal cord
injury (SCI) has remained a challenge. An effective treatment for SCI would not only reduce …

[图书][B] Introduction to nanoscience and nanotechnology

GL Hornyak, HF Tibbals, J Dutta, JJ Moore - 2008 - api.taylorfrancis.com
The maturation of nanotechnology has revealed it to be a unique and distinct discipline
rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry …

National Athletic Trainers' Association position statement: preventing sudden death in sports

DJ Casa, KM Guskiewicz… - Journal of athletic …, 2012 - meridian.allenpress.com
Objective: To present recommendations for the prevention and screening, recognition, and
treatment of the most common conditions resulting in sudden death in organized sports …

Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel

AJ Mothe, RY Tam, T Zahir, CH Tator, MS Shoichet - Biomaterials, 2013 - Elsevier
Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration,
and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a …

[HTML][HTML] Advances in stem cell therapy for spinal cord injury

AJ Mothe, CH Tator - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …