Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

Opium poppy (Papaver somniferum) is one of the world's oldest medicinal plants and
remains the only commercial source for the narcotic analgesics morphine, codeine and semi …

Amaryllidaceae alkaloids are a group of specialized metabolites found predominantly in the
Amaryllidaceae plant family. Approximately 600 naturally occurring Amaryllidaceae …

Natural products and their derivatives play an important role in modern healthcare as
frontline treatments for many diseases and as inspiration for chemically synthesized …

Recent advances in metabolic engineering enable the production of high-value chemicals
via expressing complex biosynthetic pathways in a single microbial host. However, many …

Opiates such as morphine and codeine are mainly obtained by extraction from opium
poppies. Fermentative opiate production in microbes has also been investigated, and …

Aliphatic α, ω‐dicarboxylic acids (DCAs) are a class of useful chemicals that are currently
produced by energy-intensive, multistage chemical oxidations that are hazardous to the …

Natural products produced by microorganisms and plants are a major resource of
antibacterial and anticancer drugs as well as industrially useful compounds. However, the …

Highlights•Metabolic engineering enables the microbial production of many compounds.•
Advances in engineering of yeast for production of valuable isoprenoids and aromatics are …

Highlights•Modular co-culture engineering for the production of natural
products.•Advantages of modular co-culture engineering in the field of …