Aromatic compounds derived from aromatic amino acids are an important class of diverse
chemicals with a wide range of industrial and commercial applications. They are currently …

Highlights•Extraction of many alkaloids from plants provides low and instable
yields.•Microbial cells as alternative alkaloid production systems include bacteria and …

Cytochrome P450 monooxygenases (P450s) catalyze a wide variety of monooxygenation
reactions in primary and secondary metabolism in plants. The share of P450 genes in each …

Many drugs and drug precursors found in natural organisms are rather difficult to synthesize
chemically and to extract in large amounts. Metabolic engineering is playing an increasingly …

Bioactive substances (BAS) of plant origin are known to play a very important role in modern
medicine. Their use, however, is often limited by availability of plant resources and may …

Background Synthetic biology is used to develop cell factories for production of chemicals by
constructively importing heterologous pathways into industrial microorganisms. In this work …

Pathogenesis‐related (PR) proteins constitute a broad class of plant proteins with
analogues found throughout nature from bacteria to higher eukaryotes. PR proteins were …

Coumarins are plant secondary metabolites that have demonstrated a variety of important
therapeutic properties, such as antibacterial, anti-inflammatory, and anti-coagulant effects …

Plant alkaloids have a rich chemical ecology that has been exploited for medicinal purposes
for thousands of years. Despite being highly represented within today's pharmacopoeia …

Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern
medicines. Recent studies on the microbial production of benzylisoquinolines have …