Burkholderia pseudomallei Complex Subunit and Glycoconjugate Vaccines and Their Potential to Elicit Cross-Protection to Burkholderia cepacia Complex

AJ Badten, AG Torres - Vaccines, 2024 - mdpi.com
Burkholderia are a group of Gram-negative bacteria that can cause a variety of diseases in
at-risk populations. B. pseudomallei and B. mallei, the etiological agents of melioidosis and …

Intranasal immunization with a Bucl8-based vaccine ameliorates bacterial burden and pathological inflammation, and promotes an IgG2a/b dominant response in an …

M Grund, SJ Choi, L Powell, S Lukomski - Frontiers in Immunology, 2023 - frontiersin.org
Burkholderia pseudomallei is a gram-negative bacterium that is the etiological agent of the
tropical disease melioidosis. Currently, there is no licensed vaccine for melioidosis, but …

Layered and integrated medical countermeasures against Burkholderia pseudomallei infections in C57BL/6 mice

CP Klimko, JL Shoe, NO Rill, M Hunter… - Frontiers in …, 2022 - frontiersin.org
Burkholderia pseudomallei, the gram-negative bacterium that causes melioidosis, is
notoriously difficult to treat with antibiotics. A significant effort has focused on identifying …

Identification of Burkholderia cepacia strains that express a Burkholderia pseudomallei-like capsular polysaccharide

MN Burtnick, DAB Dance, M Vongsouvath… - Microbiology …, 2024 - Am Soc Microbiol
Burkholderia pseudomallei and Burkholderia cepacia are Gram-negative, soil-dwelling
bacteria that are found in a wide variety of environmental niches. While B. pseudomallei is …

Efficacy of Treatment with the Antibiotic Novobiocin against Infection with Bacillus anthracis or Burkholderia pseudomallei

CP Klimko, SL Welkos, JL Shoe, S Mou, M Hunter… - Antibiotics, 2022 - mdpi.com
The microbial pathogens Burkholderia pseudomallei and Bacillus anthracis are unrelated
bacteria, yet both are the etiologic agents of naturally occurring diseases in animals and …

LVS ΔcapB-vectored multiantigenic melioidosis vaccines protect against lethal respiratory Burkholderia pseudomallei challenge in highly sensitive BALB/c mice

MV Tullius, RA Bowen, PS Back, S Masleša-Galić… - Mbio, 2024 - Am Soc Microbiol
Melioidosis, caused by the intracellular bacterial pathogen and Tier 1 select agent
Burkholderia pseudomallei (Bp), is a highly fatal disease endemic in tropical areas. No …

Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

KB Barnes, P Brett, M Burtnick, A Vente… - Infection and …, 2024 - Am Soc Microbiol
Melioidosis is a disease that is difficult to treat due to the causative organism, Burkholderia
pseudomallei being inherently antibiotic resistant and it having the ability to invade, survive …

Assessment of CD200R Activation in Combination with Doxycycline in a Model of Melioidosis

RE Thom, ED Williamson, J Casulli… - Microbiology …, 2023 - Am Soc Microbiol
Antimicrobial resistance continues to be a global issue. Pathogens, such as Burkholderia
pseudomallei, have evolved mechanisms to efflux certain antibiotics and manipulate the …

[HTML][HTML] BpOmpW antigen administered with CAF01 adjuvant stimulates comparable T cell responses to Sigma adjuvant system

J Tomás-Cortázar, C Quinn, N Corcoran, A Blanco… - Vaccine: X, 2024 - Elsevier
There are no licensed vaccines to protect vulnerable populations from the potentially fatal
tropical infection, melioidosis, despite its causative agent, Burkholderia pseudomallei, being …

Detection of low-level animal-to-animal transmission in BALB/c mouse models of melioidosis

CP Klimko, KB Barnes, NO Rill, JL Shoe… - Frontiers in …, 2023 - frontiersin.org
Burkholderia pseudomallei, the causative agent of melioidosis, has two phases of infection.
The acute phase occurs shortly after infection and is associated with bacterial sepsis …