Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Abstract Coronavirus disease 2019 (COVID-19) is associated with extreme inflammatory
response, disordered hemostasis and high thrombotic risk. A high incidence of …

Fibrin is a major component of thrombi formed on the surface of atherosclerotic plaques.
Fibrin accumulation as a consequence of local blood coagulation activation takes place …

In response to vessel injury (or other pathological conditions), the hemostatic process is
activated, resulting in a fibrous, cellular-rich structure commonly referred to as a blood clot …

Histones released into circulation as neutrophil extracellular traps are causally implicated in
the pathogenesis of arterial, venous, and microvascular thrombosis by promoting …

BACKGROUND Fibrinogen is a large (340 kDa) hexameric glycoprotein expressed by
hepatocytes. 1 Fibrinogen is encoded by 3 different genes (FGA, FGB, and FGG) and …

The fibrinolytic system is a key player in keeping the haemostatic balance, and changes in
fibrinolytic capacity can lead to both bleeding-related and thrombosis-related disorders. Our …

Despite improved diagnosis and treatment options, coronary artery disease (CAD) is still the
leading cause of mortality and morbidity worldwide. Established risk factors such as …

Venous thromboembolism is associated with formation of denser fibrin clots resistant to lysis.
We investigated whether prothrombotic plasma clot properties are associated with the …

Thrombosis, resulting in occlusive blood clots, blocks blood flow to downstream organs and
causes life-threatening conditions such as heart attacks and strokes. The administration of …