Neural functions of hypothalamic oxytocin and its regulation

P Wang, SC Wang, X Liu, S Jia, X Wang, T Li… - ASN …, 2022 - journals.sagepub.com
Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT
over past decades, our understanding of its neural functions and their regulation remains …

Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies

H Goel, V Kalra, SK Verma, SK Dubey… - Journal of Controlled …, 2022 - Elsevier
Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …

Sniffing oxytocin: Nose to brain or nose to blood?

S Yao, Y Chen, Q Zhuang, Y Zhang, C Lan, S Zhu… - Molecular …, 2023 - nature.com
In recent years ample studies have reported that intranasal administration of the
neuropeptide oxytocin can facilitate social motivation and cognition in healthy and clinical …

Intranasal oxytocin attenuates cognitive impairment, β-amyloid burden and tau deposition in female rats with Alzheimer's disease: interplay of ERK1/2/GSK3β/caspase …

SO El-Ganainy, OA Soliman, AA Ghazy, M Allam… - Neurochemical …, 2022 - Springer
Oxytocin is a neuropeptide hormone that plays an important role in social bonding and
behavior. Recent studies indicate that oxytocin could be involved in the regulation of …

Nose-to-brain drug delivery: challenges and progress towards brain targeting in the treatment of neurological disorders

M Raghav, V Gupta, R Awasthi, A Singh… - Journal of Drug Delivery …, 2023 - Elsevier
Delivery of therapeutics to the central nervous system for treating psychiatric and
neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, is a …

Neural circuit control of innate behaviors

W Xiao, ZL Jiao, E Senol, J Yao, M Zhao… - Science China Life …, 2022 - Springer
All animals possess a plethora of innate behaviors that do not require extensive learning
and are fundamental for their survival and propagation. With the advent of newly-developed …

Role of oxytocin in different neuropsychiatric, neurodegenerative, and neurodevelopmental disorders

AA Ghazy, OA Soliman, AI Elbahnasi, AY Alawy… - Reviews of physiology …, 2022 - Springer
Oxytocin has recently gained significant attention because of its role in the pathophysiology
and management of dominant neuropsychiatric disorders. Oxytocin, a peptide hormone …

Heteromerization of dopamine D2 and oxytocin receptor in adult striatal astrocytes

S Amato, M Averna, D Guidolin, C Ceccoli… - International Journal of …, 2023 - mdpi.com
The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-
OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly …

Impact of magnesium on oxytocin receptor function

VN Bharadwaj, J Meyerowitz, B Zou, M Klukinov, N Yan… - Pharmaceutics, 2022 - mdpi.com
Simple Summary What is already known: Mg2+ levels modulate the affinity of oxytocin
receptors for oxytocin in vitro, low serum Mg2+ is correlated with migraine headache onset …

[HTML][HTML] Towards better hypothesis tests in oxytocin research: Evaluating the validity of auxiliary assumptions

DS Quintana - Psychoneuroendocrinology, 2022 - Elsevier
Various factors have been attributed to the inconsistent reproducibility of human oxytocin
research in the cognitive and behavioral sciences. These factors include small sample sizes …