Expression of protein-coding genes in eukaryotes relies on the coordinated action of many
sophisticated molecular machineries. Transcription produces precursor mRNAs (pre …

A nuclear mRNA degradation (DRN) system was identified from analysis of mRNA turnover
rates in nup116-Δ strains of Saccharomyces cerevisiae lacking the ability to export all RNAs …

The emerging field of nuclear eIF research has yielded many surprises and led to the
dissolution of some dogmatic/ideological viewpoints of the place of translation in the …

Salivary gland cells in the larvae of the dipteran Chironomus tentans offer unique
possibilities to visualize the assembly and nucleocytoplasmic transport of a specific …

The N7‐methylguanosine cap is a hallmark of the 5′ end of eukaryotic mRNAs and is
required for gene expression. Loss of the cap was believed to lead irreversibly to decay …

In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export
(TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have …

Nucleocytoplasmic transport is a complex process that consists of the movement of
numerous macromolecules back and forth across the nuclear envelope. All macromolecules …

Background: The transport of macromolecules between the nucleus and cytoplasm is an
energy-dependent process. Substrates are translocated across the nuclear envelope …

ABSTRACT The Nuclear Pore Complex (NPC) regulates nucleocytoplasmic transport by
providing small channels for passive diffusion and multiple docking surfaces that lead to a …

Mammalian mRNAs lose and acquire proteins throughout their life span while undergoing
processing, transport, translation, and decay. How translation affects messenger RNA …