Rodent cells are notable for their inability to support normal assembly of HIV particles. In this
report, we address possible causes for this defect by considering the hypothesis that mRNA …

The eukaryotic initiation factor 4E (eIF4E) plays a pivotal role in the control of protein
synthesis. eIF4E binds to the mRNA 5′ cap structure, m7GpppN (where N is any …

A major challenge in current molecular biology is to understand how sequential steps in
gene expression are coupled. Recently, much attention has been focused on the linkage of …

▪ Abstract Eukaryotic cells evolved when their genetic information was packed into the cell
nucleus. DNA replication and RNA biogenesis occur inside the nucleus while protein …

The yeast Saccharomyces cerevisiae contains three proteins (Kap104p, Pse1p, and
Kap123p) that share similarity to the 95-kDa β subunit of the nuclear transport factor importin …

In mammalian cells, poly (A) binding protein C1 (PABP C1) has well-known roles in mRNA
translation and decay in the cytoplasm. However, PABPC1 also shuttles in and out of the …

After the processing of pre–messenger RNA (pre-mRNA) nucleoproteins examined usually
display characteristic, in the cell nucleus, the mature messsenger RNA (mRNA) often …

▪ Abstract RNA molecules synthesized in the nucleus are transported to their sites of function
throughout the eukaryotic cell by specific transport pathways. This review focuses on …

Eukaryotic mRNA is processed by enzymes and packaged with proteins within nuclei to
generate functional messenger ribonucleoprotein (mRNP) particles. Processing and …

The mRNA cap structure is bound by either the nuclear (CBC) or the cytoplasmic (eIF4F) cap
binding complex. Following mRNA export, CBC must be exchanged for eIF4F in the …