The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …

Voluntary exercise produces a dramatic increase in the number of bromodeoxyuridine
(BrdU)‐positive cells in the adult dentate gyrus (DG); however, it has never been determined …

What are the processes, from conception to adulthood, that enable a single cell to grow into
a sentient adult? The processes that occur along the way are so complex that any attempt to …

The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …

Ca 2+ influx through N-methyl-D-aspartate–(NMDA–) type glutamate receptors plays a
critical role in synaptic plasticity in the brain. One of the proteins activated by the increase in …

We report that CaM kinase IV and CREB play a critical role in mediating calcium-induced
dendritic growth in cortical neurons. Calcium-dependent dendritic growth is suppressed by …

Daily restraint for 3 weeks was shown to atrophy dendrites of hippocampal pyramidal
neurons in rats. Brain-derived neurotrophic factor (BDNF), which maintains neuronal …

A signaling pathway by which calcium influx regulates the expression of the major activity-
dependent transcript of BDNF in cortical neurons has been elucidated. Deletion and …

Development of the Nervous System presents a broad and basic treatment of the
established and evolving principles of neural development as exemplified by key …

Dendritic arborization is required for proper neuronal connectivity. Rho GTPases have been
implicated in the regulation of dendrite development. However, the signaling pathways that …