The neurotrophins are best known for their ability to support neuronal survival and
differentiation, but a role in synapse formation and plasticity has recently emerged. For …

A principal objective of spinal cord injury (SCI) research is the restoration of axonal
connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms …

Recent technical advances have made possible the visualization and genetic manipulation
of individual dendritic trees. These studies have led to the identification and characterization …

To examine functions of TrkB in the adult CNS, TrkB has been removed from neurons
expressing CaMKII, primarily pyramidal neurons, using Cre-mediated recombination. A …

Neurotrophin regulation of neuronal morphology is complex and may involve differential
action of alternative Trk receptor isoforms. We transfected ferret visual cortical slices with full …

Neurotrophins are traditionally thought to be secretory proteins that regulate long‐term
survival and differentiation of neurons. Recent studies have revealed a previously …

Slit proteins have previously been shown to regulate axon guidance, branching, and neural
migration. Here we report that, in addition to acting as a chemorepellant for cortical axons …

Dendrites serve a critical role in neuronal information processing as sites of synaptic
integration. The morphological diversity of dendritic architecture reflects specialized …

Although dendrite arborization patterns are hallmarks of neuronal type and critical
determinants of neuronal function, how dendritic arbors take shape is still largely unknown …

In humans, mutations in the L1 cell adhesion molecule are associated with a neurological
syndrome termed CRASH, which includes corpus callosum agenesis, mental retardation …