The storage of information in the mammalian nervous systems is dependent on a delicate
balance between change and stability of neuronal networks. The induction and …

Recent studies have suggested a role for neurotrophins in the growth and refinement of
neural connections, in dendritic growth, and in activity-dependent adult plasticity. To unravel …

The neurotrophins, a class of four related growth factors, utilize a dual receptor system
consisting of Trk receptor tyrosine kinases and the structurally unrelated p75 NTR to …

Microelectrode recordings and optical imaging of intrinsic signals were used to define the
critical period for susceptibility to monocular deprivation (MD) in the primary visual cortex of …

Expression of the neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor
trkB in the ganglion cell layer of the Xenopus retina during retinal ganglion cell (RGC) …

Brain-derived neurotrophic factor (BDNF) exerts prominent effects on hippocampal neurons,
but the mechanisms that initiate its actions are poorly understood. We report here that BDNF …

Neurotrophins acting at the trkB receptor have been shown to be important modulators of
activity-dependent plasticity in the hippocampus, but the mechanisms underlying these …

A considerable body of evidence links diminished brain-derived neurotrophic factor (BDNF)
signaling to energy balance dysregulation and severe obesity in humans and rodents …

Tumor necrosis factor alpha (TNFα) is a cytokine produced mainly by cells of the immune
system. It is also expressed by brain neurons and glia. The physiological role of TNFα in the …

Autism is a complex, behaviorally defined, developmental brain disorder with an estimated
prevalence of 1 in 1,000. It is now clear that autism is not a disease, but a syndrome with a …