Reorganization of the actin cytoskeleton is essential for cellular processes during animal
development. Cofilin and actin depolymerizing factor (ADF) are potent actin‐binding …

Patients with schizophrenia have reduced neurotrophin levels in their dorsolateral prefrontal
cortex (DLPFC) compared to normal unaffected individuals. The tyrosine kinase-containing …

Evidence implicates environmental factors in the pathogenesis of Autism Spectrum
Disorders (ASD). However, the identity of specific environmental chemicals that influence …

Neocortical pyramidal neurons respond to prolonged activity blockade by modulating their
balance of inward and outward currents to become more sensitive to synaptic input, possibly …

Mental actions are based on the dynamic organization of neuronal networks. In particular,
phylogenetically young brain areas (eg, cortical associative circuits) involved in the …

To illuminate the function of the thousands of genes that make up the complexity of the
nervous system, it is critical to be able to introduce and express DNA in neurons. Over the …

Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal
muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal …

Brain-derived neurotrophic factor (BDNF) has been postulated to be a key signaling
molecule in regulating synaptic strength and overall circuit activity. In this context, we have …

Although recent studies indicate that brain-derived neurotrophic factor (BDNF) plays an
important role in hippocampal synaptic plasticity, the underlying signaling mechanisms …

Neurotrophin signaling is crucial for neuron growth. While the" signaling endosomes"
hypothesis is one of the accepted models, the molecular machinery that drives retrograde …