Invasive candidiasis (IC) is a leading cause of mycosis-associated mortality in the United
States. We examined data from the National Center for Health Statistics and reviewed recent …

The echinocandins are large lipopeptide molecules that are inhibitors of β-(1, 3)-glucan
synthesis, an action that damages fungal cell walls. In vitro and in vivo, the echinocandins …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Aspergillus species have emerged as an important cause of life-threatening infections in
immunocompromised patients. This expanding population is composed of patients with …

Fungi are increasingly recognised as major pathogens in critically ill patients. Candida spp.
and Cryptococcus spp. are the yeasts most frequently isolated in clinical practice. The most …

Management of coccidioidomycosis first involves recognizing that a coccidioidal infection
exists, defining the extent of infection, and identifying host factors that predispose to disease …

Patient characteristics, antifungal prophylaxis, and other factors appear to have contributed
to a change in the spectrum of invasive fungal pathogens. Infections with Candida glabrata …

Morbidity and mortality caused by invasive Aspergillus infections are increasing. This is
because of the higher number of patients with malignancies treated with intensive …

The persistence of high morbidity and mortality from systemic fungal infections despite the
availability of novel antifungals points to the need for effective treatment strategies …

BACKGROUND: Micafungin (FK463) is a new lipopeptide compound (echinocandin) with
activity against Aspergillus and Candida species. This study evaluated the safety and …