Isoliquiritigenin ameliorates acute pancreatitis in mice via inhibition of oxidative stress and modulation of the Nrf2/HO‐1 pathway

X Liu, Q Zhu, M Zhang, T Yin, R Xu… - Oxidative medicine …, 2018 - Wiley Online Library
Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP).
Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However …

[HTML][HTML] Biochemical evaluation of the antioxidant effects of hydroxytyrosol on pancreatitis-associated gut injury

R Fusco, M Cordaro, R Siracusa, R D'Amico… - Antioxidants, 2020 - mdpi.com
Acute pancreatitis is a severe abdominal pathology often associated with several
complications including gut dysfunction. Oxidative stress is one of the most important …

Formononetin administration ameliorates dextran sulfate sodium‐induced acute colitis by inhibiting NLRP3 inflammasome signaling pathway

D Wu, K Wu, Q Zhu, W Xiao, Q Shan… - Mediators of …, 2018 - Wiley Online Library
Formononetin is a kind of isoflavone compound and has been reported to possess anti‐
inflammatory properties. In this present study, we aimed to explore the protective effects of …

Pain and its Management in Severe Acute Pancreatitis

Y Long, Z Jiang, G Wu - Journal of Translational Critical Care …, 2022 - journals.lww.com
Pain is common in severe acute pancreatitis (SAP) and is associated with the disease
severity and outcomes. The management of pain in SAP may not only relieve pain but also …

[HTML][HTML] KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage

A Ergashev, F Shi, Z Liu, Z Pan, H Xie, L Kong… - Free Radical Biology …, 2024 - Elsevier
Acute pancreatitis (AP) is a non-infectious pancreatic enzyme-induced disorder, a life-
threatening inflammatory condition that can cause multi-organ dysfunction, characterized by …

[HTML][HTML] Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway

Q Zhang, X Tao, S Xia, J Qu, H Song… - Oncology …, 2019 - spandidos-publications.com
Acute pancreatitis (AP) is an aseptic inflammation characterized with an annual incidence
rate, and~ 20% patients progressing to severe AP (SAP) with a high mortality rate. Although …

Reorienting of pramipexole as a promising therapy for acute pancreatitis in a rat model by suppressing TLR4\NF-κB p65\NLRP3 inflammasome signaling

HA Fawzy, AA Mohammed, HM Fawzy… - Canadian Journal of …, 2022 - cdnsciencepub.com
Acute pancreatitis (AP), a disorder of global importance, has a growing incidence and
prevalence, particularly in the Western world. Its complications include pseudocysts and …

[HTML][HTML] Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway

C Luo, Q Huang, X Yuan, Y Yang, B Wang, Z Huang… - Apoptosis, 2020 - Springer
Our previous studies have shown that abdominal paracentesis drainage (APD) is a safe and
effective strategy for patients with severe acute pancreatitis (SAP). However, the underlying …

The possible protective effect of Nano-Selenium on the endocrine and exocrine pancreatic functions in a rat model of acute pancreatitis

EA Abdel-Hakeem, HA Abdel-Hamid… - Journal of Trace Elements …, 2020 - Elsevier
Background Acute pancreatitis is a serious condition with multi-factorial etiology. The
negative impact of acute pancreatitis on the exocrine pancreatic function is well …

CaMK II inhibition attenuates ROS dependent necroptosis in acinar cells and protects against acute pancreatitis in mice

Q Zhu, L Hao, Q Shen, J Pan, W Liu… - Oxidative medicine …, 2021 - Wiley Online Library
As a calcium‐regulated protein, CaMK II is closely related to cell death, and it participates in
the development of pathological processes such as reperfusion injury, myocardial infarction …